PENICILLIN B, AN ANTIBACTERIAL SUBSTANCE FROM PENICILLIUM NOTATUM
نویسندگان
چکیده
منابع مشابه
A Comparison of Penicillin-producing Strains of Penicillium notatum-chrysogenum.
Sampling and storage. The fermentations were conducted in the 100-gallon tanks described by Stefaniak et al. (1946). Samples were removed periodically into 500-ml flasks and ifitered. A 0.5-ml filtered sample was immediately diluted for penicillin assay by addition to previously chilled phosphate buffer in volumetric flasks (4.0 g KH2P04 and 1.0 g K2HPO4 per 500 ml solution in distilled water; ...
متن کاملReminiscence of phospholipase B in Penicillium notatum
Since the phospholipase B (PLB) was reported as a deacylase of both lecithin and lysolecithin yielding fatty acids and glycerophosphocholine (GPC), there was a question as to whether it is a single enzyme or a mixture of a phospholipase A2 (PLA2) and a lysophospholipase (LPL). We purified the PLB in Penicillium notatum and showed that it catalyzed deacylation of sn-1 and sn-2 fatty acids of 1,2...
متن کاملMicrobiological Aspects of Penicillin: III. Production of Penicillin in Surface Cultures of Penicillium notatum.
Steadily increasing interest in penicillin as a chemotherapeutic agent has led to a parallel increase in the demand for penicillin for clinical application and chemical studies. Penicillin is produced in minute quantities by Penicillium notatum so that filtrates from the mold represent exceedingly dilute solutions of penicillin from which the active agent is extracted. The magnitude of the prob...
متن کاملFrom Two Strains of Penicillium Notatum
This paper is the second of a series dealing with the analysis of penicillin by means of a chromatogram using solvent-phosphate buffer partition on a silica base. The first paper (Levi, 1948) described the development of this type of chromatogram which is based on that ofMartin & Synge (1941), and outlined the principles of its application to the study of penicillin. The work described was carr...
متن کاملCultural Characteristics of Penicillium Notatum in Relation to the Production of Antibacterial Substance: Indication of the Dual Nature of the Antibacterial Substance.
Of the bacterial antagonists thus far known to be produced by microorganisms, the most effective in bactericidal action against Brucella abortus is the culture filtrate from a strain of Penicillium notatum (Kocholaty, 1942). Another antibacterial substance, penicillin, also obtained from a culture of a strain of Penicillium notatum, but with very little potency against Brucella abortus, has bee...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1943
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)72411-3